• It looks like Azerbaijan’s claims of victory in Nagorno-Karabakh were actually real news: Armenia agreed to a ceasefire today, and it’s far more comprehensive and permanent-looking than the last two that failed quickly.

  • Russia brokered the deal, which will see almost 2,000 Russian peacekeepers patrol the region after Armenian troops fully withdraw.

  • Armenians are protesting their government’s concession, while Azerbaijanis are celebrating a deal seen as a win for their side.


  • Pres. Trump’s campaign has avoided any mention of conceding and any cooperation with Pres.-elect Biden’s transition team, and instead is spreading baseless claims of voter fraud in Biden’s favor. Even Fox News cut off Trump’s press secretary Kayleigh McEnany’s opening press conference statement after McEnany repeated those fraud claims: “I can’t in good countenance continue to show you this.”

  • Trump still has his supporters, though: Senate Majority Leader Mitch McConnell said Trump was “100 percent within his rights” to challenge the election outcome, and only four Republican senators have recognized Biden’s win.

  • Trump fired SecDef Esper yesterday, weeks after Esper publicly disagreed with Trump’s use of the military to quell protests.


  • A coronavirus vaccine developed by Pfizer and BioNTech showed the best promise of any vaccine candidate yet by reducing the number of symptomatic COVID cases by 90% among trial participants. Stock markets rejoiced on the news that this vaccine could start to be introduced to the public in December (starting with the elderly and healthcare workers). An AP article pasted below has more.

  • On the other hand, China’s Sinovac vaccine isn’t faring as well: Brazil’s health regulator stopped late-stage trials after a “severe adverse event.” But Russia’s Sputnik V vaccine is doing great, according to its Twitter account (yes, the vaccine actually has its own Twitter account).


  • Islamic State-linked militants attacked several villages in Cabo Delgado, Mozambique over the weekend, beheading at least 50 people in a gruesome stadium massacre. There were similar attacks there in April, when attackers beheaded and shot over 50 youth—allegedly for refusing to join the jihadists.


  • PM Abiy continued to escalate a military offensive in Tigray, using air strikes as part of a “law enforcement operation.” There are reports of heavy fighting, leading some analysts to worry about a looming civil war.


  • Venezuela’s opposition-held Congress reported that the economy contracted 50% in Q3 2020 vs. Q3 2019, due to the combined effect of the pandemic and a collapse in the country’s sanctioned oil sector. The government doesn’t publish regular economic indicators, so this may be the best glimpse we get into the Venezuelan economy.

Maritime Security

  • There was indeed another attempted pirate attack on a tanker in the Gulf of Guinea, but it was thwarted like the last two recent attempts. If the attackers are the same crew or group, they’re likely getting increasingly frustrated and desperate, and will probably try again.

Other News

  • Peru’s Congress ousted Pres. Vizcarra on corruption allegations, sending him to a second round of impeachment trials. Peru is #2 in copper production, so prolonged upheaval would likely affect copper prices.

  • A Russian soldier killed three officers at a military base in the southern region of Voronezh. Russia says it’s investigating the attacker’s motives, but we might not learn the real story: such “investigations” tend to use mental health issues as a scapegoat in cases that were actually terrorism.

Pfizer says COVID-19 vaccine is looking 90% effective (AP)

Pfizer Inc. said Monday that its COVID-19 vaccine may be a remarkable 90% effective, based on early and incomplete test results that nevertheless brought a big burst of optimism to a world desperate for the means to finally bring the catastrophic outbreak under control.

The announcement came less than a week after an election seen as a referendum on President Donald Trump’s handling of the scourge, which has killed more than 1.2 million people worldwide, including almost a quarter-million in the United States alone.

“We’re in a position potentially to be able to offer some hope,” Dr. Bill Gruber, Pfizer’s senior vice president of clinical development, told The Associated Press. “We’re very encouraged.”

Pfizer, which is developing the vaccine with its German partner BioNTech, now is on track to apply later this month for emergency-use approval from the U.S. Food and Drug Administration, once it has the necessary safety information in hand.

Even if all goes well, authorities have stressed it is unlikely any vaccine will arrive much before the end of the year, and the limited initial supplies will be rationed.

Dr. Anthony Fauci, the U.S. government’s top infectious-disease expert, said the results suggesting 90% effectiveness are “just extraordinary,” adding: “Not very many people expected it would be as high as that.”

“It’s going to have a major impact on everything we do with respect to COVID,” Fauci said as Pfizer appeared to take the lead in the all-out global race by pharmaceutical companies and various countries to develop a well-tested vaccine against the virus.

Dr. Bruce Aylward, the World Health Organization’s senior adviser, said Pfizer’s vaccine could “fundamentally change the direction of this crisis” by March, when the U.N. agency hopes to start vaccinating high-risk groups.

Global markets, already buoyed by the victory of President-elect Joe Biden, rallied on the news from Pfizer. The S&P 500 finished the day with a gain of 1.2%, while the Dow Jones Industrial Average rose more than 800 points. Pfizer stock was up more than 8%.

Still, Monday’s announcement doesn’t mean for certain that a vaccine is imminent: This interim analysis, from an independent data monitoring board, looked at 94 infections recorded so far in a study that has enrolled nearly 44,000 people in the U.S. and five other countries.

Some participants got the vaccine, while others got dummy shots. Pfizer released no specific breakdowns, but for the vaccine to be 90% effective, nearly all the infections must have occurred in placebo recipients. The study is continuing, and Pfizer cautioned that the protection rate might change as more COVID-19 cases are added to the calculations.

Dr. Jesse Goodman of Georgetown University, former chief of the FDA’s vaccine division, called the partial results “extremely promising” but ticked off many questions still to be answered, including how long the vaccine’s effects last and whether it protects older people as well as younger ones.

Trump, who had suggested repeatedly during the presidential campaign that a vaccine could be ready by Election Day, tweeted: “STOCK MARKET UP BIG, VACCINE COMING SOON. REPORT 90% EFFECTIVE. SUCH GREAT NEWS!”

Biden, for his part, welcomed the news but cautioned that it could be many months before vaccinations become widespread in the U.S., and he warned Americans to rely on masks and social distancing in the meantime. He said the country still faces a “dark winter.”

Confirmed infections in the U.S. eclipsed 10 million on Monday, the highest in the world. New cases are running at all-time highs of more than 100,000 per day. And tens of thousands more deaths are feared in the coming months, with the onset of cold weather and the holidays.

Pfizer’s vaccine is among four candidates already in huge studies in the U.S., with still more being tested in other countries. Another U.S. company, Moderna Inc., also hopes to file an application with the FDA late this month.

Both companies’ shots are made with a brand-new technology. These “mRNA vaccines” aren’t made with the coronavirus itself, meaning there’s no chance anyone could catch it from the shots. Instead, the vaccine contains a piece of genetic code that trains the immune system to recognize the spiked protein on the surface of the virus.

Despite cheering the news early on Monday, Trump posted a series of tweets later Monday accusing Pfizer and the U.S. Food and Drug Administration of waiting until after the election to announce its positive vaccine news for political reasons.

Pfizer has insisted that its work is not influenced by politics and that it was “moving at the speed of science.” The company itself learned of the interim results on Sunday after its independent data monitors met to discuss them. The FDA was not involved in Pfizer’s decision to announce its early results and did not make any announcements of its own.

Pfizer initially opted not to join the Trump administration’s Operation Warp Speed, which helped fund a half-dozen vaccine makers’ research and manufacturing scale-up. Pfizer instead said it has invested $2 billion of its own money in testing and expanding manufacturing capacity. But in July, Pfizer signed a contract to supply the U.S. with 100 million doses for $1.95 billion, assuming the vaccine is cleared by the FDA.

Pfizer said its only involvement in Operation Warp Speed is that those doses are part of the administration’s goal to have 300 million doses of COVID-19 vaccines ready sometime next year.

The strong results were a surprise. Scientists have warned for months that any COVID-19 shot may be only as good as flu vaccines, which are about 50% effective and require yearly immunizations. Earlier this year, Fauci said he would be happy with a COVID-19 vaccine that was 60% effective.

Whatever the ultimate level of protection, no one knows if people will need regular vaccinations.

Also, volunteers in the study received a coronavirus test only if they developed symptoms, leaving unanswered whether vaccinated people could get infected but show no symptoms and unknowingly spread the virus.

Pfizer has estimated it could have 50 million doses available globally by the end of 2020, enough for 25 million people.

Public Citizen, the consumer advocacy group, called the release of the preliminary and incomplete data “bad science” and said that any enthusiasm over the results “must be tempered” until they are reviewed by the FDA and its independent experts.

“Crucial information absent from the companies’ announcement is any evidence that the vaccine prevents serious COVID-19 cases or reduces hospitalizations and deaths due to the disease,” the organization said.

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